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    • Assessing the physiological effects of traditional regional diets targeting the prevention of cardiovascular disease: A systematic review of randomized controlled trials implementing mediterranean, New Nordic, Japanese, Atlantic, Persian and Mexican dietary interventions 

      Klonizakis M., Bugg A., Hunt B., Theodoridis X., Bogdanos D.P., Grammatikopoulou M.G. (2021)
      Traditional regional diets are considered as sustainable dietary patterns, while many have been examined with regard to their health benefits. The aim of the present systematic review was to aggerate all evidence on the ...

    • Comparative Efficacy of 5 Exercise Types on Cardiometabolic Health in Overweight and Obese Adults: A Systematic Review and Network Meta-Analysis of 81 Randomized Controlled Trials 

      Batrakoulis A., Jamurtas A.Z., Metsios G.S., Perivoliotis K., Liguori G., Feito Y., Riebe D., Thompson W.R., Angelopoulos T.J., Krustrup P., Mohr M., Draganidis D., Poulios A., Fatouros I.G. (2022)
      Background: Although regular exercise is recommended for preventing and treating overweight/obesity, the most effective exercise type for improving cardiometabolic health in individuals with overweight/obesity remains ...

    • Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study 

      Domenighetti C., Sugier P.-E., Ashok Kumar Sreelatha A., Schulte C., Grover S., Mohamed O., Portugal B., May P., Bobbili D.R., Radivojkov-Blagojevic M., Lichtner P., Singleton A.B., Hernandez D.G., Edsall C., Mellick G.D., Zimprich A., Pirker W., Rogaeva E., Lang A.E., Koks S., Taba P., Lesage S., Brice A., Corvol J.-C., Chartier-Harlin M.-C., Mutez E., Brockmann K., Deutschländer A.B., Hadjigeorgiou G.M., Dardiotis E., Stefanis L., Simitsi A.M., Valente E.M., Petrucci S., Duga S., Straniero L., Zecchinelli A., Pezzoli G., Brighina L., Ferrarese C., Annesi G., Quattrone A., Gagliardi M., Matsuo H., Kawamura Y., Hattori N., Nishioka K., Chung S.J., Kim Y.J., Kolber P., van de Warrenburg B.P.C., Bloem B.R., Aasly J., Toft M., Pihlstrøm L., Correia Guedes L., Ferreira J.J., Bardien S., Carr J., Tolosa E., Ezquerra M., Pastor P., Diez-Fairen M., Wirdefeldt K., Pedersen N.L., Ran C., Belin A.C., Puschmann A., Hellberg C., Clarke C.E., Morrison K.E., Tan M., Krainc D., Burbulla L.F., Farrer M.J., Krüger R., Gasser T., Sharma M., Elbaz A., and the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium (2022)
      Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or ...

    • Effect of pomegranate juice consumption on biochemical parameters and complete blood count 

      Manthou E., Georgakouli K., Deli C.K., Sotiropoulos A., Fatouros I.G., Kouretas D., Haroutounian S., Matthaiou C., Koutedakis Y., Jamurtas A.Z. (2017)
      Pomegranate has been used therapeutically for centuries. The aim of the present study was to examine the effects of pomegranate juice (PJ) supplementation on complete blood count (CBC), glucose, blood lipids and C-reactive ...

    • The effects of exercise on cardiovascular disease risk factors and cardiovascular physiology in rheumatoid arthritis 

      Metsios G.S., Moe R.H., van der Esch M., van Zanten J.J.C.S.V., Fenton S.A.M., Koutedakis Y., Vitalis P., Kennedy N., Brodin N., Bostrom C., Swinnen T.W., Tzika K., Niedermann K., Nikiphorou E., Fragoulis G.E., Vlieland T.P.V.M., Van den Ende C.H.M., Kitas G.D., The IMPACT-RMD Consortium (2020)
      Cardiovascular disease (CVD) morbidity and mortality is highly prevalent in patients with rheumatoid arthritis (RA) with debilitating effects for the individual as well as significant healthcare impact. Current evidence ...

    • Genetic sharing with cardiovascular disease risk factors and diabetes reveals novel bone mineral density loci 

      Reppe S., Wang Y., Thompson W.K., McEvoy L.K., Schork A.J., Zuber V., LeBlanc M., Bettella F., Mills I.G., Desikan R.S., Djurovic S., Gautvik K.M., Dale A.M., Andreassen O.A., Estrada K., Styrkarsdottir U., Evangelou E., Hsu Y.-H., Duncan E.L., Ntzani E.E., Oei L., Albagha O.M.E., Amin N., Kemp J.P., Koller D.L., Li G., Liu C.-T., Minster R.L., Moayyeri A., Vandenput L., Willner D., Xiao S.-M., Yerges-Armstrong L.M., Zheng H.-F., Alonso N., Eriksson J., Kammerer C.M., Kaptoge S.K., Leo P.J., Thorleifsson G., Wilson S.G., Wilson J.F., Aalto V., Alen M., Aragaki A.K., Aspelund T., Center J.R., Dailiana Z., Duggan D.J., Garcia M., Garcia-Giralt N., Giroux S., Hallmans G., Hocking L.J., Husted L.B., Jameson K.A., Khusainova R., Kim G.S., Kooperberg C., Koromila T., Kruk M., Laaksonen M., Lacroix A.Z., Lee S.H., Leung P.C., Lewis J.R., Masi L., Mencej-Bedrac S., Nguyen T.V., Nogues X., Patel M.S., Prezelj J., Rose L.M., Scollen S., Siggeirsdottir K., Smith A.V., Svensson O., Trompet S., Trummer O., Van Schoor N.M., Woo J., Zhu K., Balcells S., Brandi M.L., Buckley B.M., Cheng S., Christiansen C., Cooper C., Dedoussis G., Ford I., Frost M., Goltzman D., González-Macías J., Kähönen M., Karlsson M., Khusnutdinova E., Koh J.-M., Kollia P., Langdahl B.L., Leslie W.D., Lips P., Ljunggren Ö., Lorenc R.S., Marc J., Mellström D., Obermayer-Pietsch B., Olmos J.M., Pettersson-Kymmer U., Reid D.M., Riancho J.A., Ridker P.M., Rousseau F., Slagboom P.E., Tang N.L.S., Urreizti R., Van Hul W., Viikari J., Zarrabeitia M.T., Aulchenko Y.S., Castano-Betancourt M., Grundberg E., Herrera L., Ingvarsson T., Johannsdottir H., Kwan T., Li R., Luben R., Medina-Gómez C., Palsson S.Th., Rotter J.I., Sigurdsson G., Van Meurs J.B.J., Verlaan D., Williams F.M.K., Wood A.R., Zhou Y., Pastinen T., Raychaudhuri S., Cauley J.A., Chasman D.I., Clark G.R., Cummings S.R., Danoy P., Dennison E.M., Eastell R., Eisman J.A., Gudnason V., Hofman A., Jackson R.D., Jones G., Jukema J.W., Khaw K.-T., Lehtimäki T., Liu Y., Lorentzon M., McCloskey E., Mitchell B.D., Nandakumar K., Nicholson G.C., Oostra B.A., Peacock M., Pols H.A.P., Prince R.L., Raitakari O., Reid I.R., Robbins J., Sambrook P.N., Sham P.C., Shuldiner A.R., Tylavsky F.A., Van Duijn C.M., Wareham N.J., Cupples L.A., Econs M.J., Evans D.M., Harris T.B., Kung A.W.C., Psaty B.M., Reeve J., Spector T.D., Streeten E.A., Zillikens M.C., Thorsteinsdottir U., Ohlsson C., Karasik D., Richards J.B., Brown M.A., Stefansson K., Uitterlinden A.G., Ralston S.H., Ioannidis J.P.A., Kiel D.P., Rivadeneira F., GEFOS Consortium (2015)
      Bone Mineral Density (BMD) is a highly heritable trait, but genome-wide association studies have identified few genetic risk factors. Epidemiological studies suggest associations between BMD and several traits and diseases, ...

    • Impact of Bariatric Surgery on Metabolic and Gut Microbiota Profile: a Systematic Review and Meta-analysis 

      Magouliotis D.E., Tasiopoulou V.S., Sioka E., Chatedaki C., Zacharoulis D. (2017)
      We aim to review the available literature on obese patients treated with bariatric procedures, in order to assess their effect on the metabolic and gut microbiota profiles. A systematic literature search was performed in ...

    • Interplay between oxidative damage, the redox status, and metabolic biomarkers during long-term fasting 

      Grundler F., Mesnage R., Goutzourelas N., Tekos F., Makri S., Brack M., Kouretas D., Wilhelmi de Toledo F. (2020)
      Obesity and its related metabolic disorders, as well as infectious diseases like covid-19, are important health risks nowadays. It was recently documented that long-term fasting improves metabolic health and enhanced the ...

    • Ketogenic therapy for Parkinson's disease: A systematic review and synthesis without meta-analysis of animal and human trials 

      Grammatikopoulou M.G., Tousinas G., Balodimou C., Anastasilakis D.A., Gkiouras K., Dardiotis E., Evangeliou A.E., Bogdanos D.P., Goulis D.G. (2022)
      Objective: The aim of the present systematic review was to assess the efficacy of ketogenic therapy in Parkinson's disease (PD), using all available data from randomized controlled trials (RCTs) on humans and animal studies ...

    • Minimal invasive technique for gene delivery in porcine liver lobe segment 

      Katsimpoulas, M.; Zacharoulis, D.; Rountas, C.; Dimitriou, C.; Mantziaras, G.; Kostomitsopoulos, N.; Habib, N.; Kostakis, A. (2011)
      Introduction: The feasibility and outcome of large volume injection of gene solution in a segment of a liver lobe, without backflow, were studied in a porcine model, using a custom-designed balloon catheter. Method: Eight ...

    • New molecular diagnostic trends and biomarkers for amyotrophic lateral sclerosis 

      Pampalakis G., Mitropoulos K., Xeromerisiou G., Dardiotis E., Deretzi G., Anagnostouli M., Katsila T., Rentzos M., Patrinos G.P. (2019)
      Amyotrophic lateral sclerosis (ALS) is a rare and fatal neurodegenerative disorder. Two forms are recognized, familial (FALS) that accounts for 5–10% of ALS cases, and sporadic (SALS) that accounts for the rest. Early ...

    • Recommendations for lipid modification in patients with ischemic stroke or transient ischemic attack: A clinical guide by the Hellenic Stroke Organization and the Hellenic Atherosclerosis Society 

      Sagris D., Ntaios G., Georgiopoulos G., Kakaletsis N., Elisaf M., Katsiki N., Korompoki E., Kypreos K.E., Boutari C., Bilianou H., Makaritsis K., Nomikos T., Papavasileiou V., Pitsavos C., Plomaritoglou A., Spengos K., Tziomalos K., Tselepis A., Vemmos K., Liberopoulos E., Milionis H. (2021)
      This document presents the consensus recommendations of the Hellenic Stroke Organization and the Hellenic Atherosclerosis Society for lipid modification in patients with ischemic stroke or transient ischemic attack. This ...

    • Serum triglyceride and cholesterol concentrations and lipoprotein profiles in dogs with naturally occurring pancreatitis and healthy control dogs 

      Xenoulis P.G., Cammarata P.J., Walzem R.L., Suchodolski J.S., Steiner J.M. (2020)
      Background: Previous studies have reported an association between hyperlipidemia and pancreatitis in dogs, but details of this association remain poorly defined. Hypothesis/Objectives: To compare serum triglyceride and ...

    • Study of insulin resistance, TNF-α, total antioxidant capacity and lipid profile in patients with chronic heart failure under exercise 

      Tsarouhas, K.; Tsitsimpikou, C.; Haliassos, A.; Georgoulias, P.; Koutsioras, I.; Kouretas, D.; Kogias, J.; Liosis, I.; Rentoukas, E.; Kyriakides, Z. (2011)
      Gluco-metabolic syndrome, oxidative stress and inflammation are common in chronic heart failure (CHF). Exercise training programmes are known to improve oxidative status, insulin sensitivity and endothelial function. In ...

    • Targeted and global pharmacometabolomics in everolimus-based immunosuppression: association of co-medication and lysophosphatidylcholines with dose requirement 

      Lesche D., Sigurdardottir V., Leichtle A.B., Nakas C.T., Christians U., Englberger L., Fiedler M., Largiadèr C.R., Mohacsi P., Sistonen J. (2018)
      Introduction: The immunosuppressive therapy with everolimus (ERL) after heart transplantation is characterized by a narrow therapeutic window and a substantial variability in dose requirement. Factors explaining this ...